| # | Spieler | Team | GP | TOT | SACK | INT | FF |
|---|---|---|---|---|---|---|---|
| 1 | DH Daiyan Henley | Chargers | 16 | 103 | 3.5 | — | — |
| 2 | TD Troy Dye | Chargers | 16 | 58 | 1.0 | — | — |
| 3 | TT Tuli Tuipulotu | Chargers | 16 | 49 | 13.0 | — | — |
| 4 | DP Denzel Perryman | Chargers | 10 | 47 | 0.0 | — | — |
| 5 | DP Del'Shawn Phillips | Chargers | 17 | 37 | 1.0 | — | — |
| 6 | KM Khalil Mack | Chargers | 12 | 32 | 5.5 | — | — |
| 7 | MW Marlowe Wax | Chargers | 17 | 21 | 0.0 | — | — |
| 8 | BD Bud Dupree | Chargers | 16 | 16 | 2.0 | — | — |
| 9 | KK Kyle Kennard | Chargers | 5 | 2 | 0.0 | — | — |